Article
Phosphatidylinositol-3-OH kinase or RAS pathway mutations in human breast cancer cell lines.
Molecular cancer research : MCR - 1 Feb 2007
Hollestelle Antoinette, Elstrodt Fons, Nagel Jord H A, Kallemeijn Wouter W, Schutte Mieke
Abstract excerpt
Constitutive activation of the phosphatidylinositol-3-OH kinase (PI3K) and RAS signaling pathways are important events in tumor formation. This is illustrated by the frequent genetic alteration of several key players from these pathways in a wide variety of human cancers. Here, we report a detailed sequence analysis of the PTEN, PIK3CA, KRAS, HRAS, NRAS, and BRAF genes in a collection of 40 human breast cancer...
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