Article
T cell development requires constraint of the myeloid regulator C/EBP-α by the Notch target and transcriptional repressor Hes1.
Nature immunology - 1 Dec 2013
De Obaldia Maria Elena, Bell J Jeremiah, Wang Xinxin, Harly Christelle, Yashiro-Ohtani Yumi, DeLong Jonathan H, Zlotoff Daniel A, Sultana Dil Afroz, Pear Warren S, Bhandoola Avinash
Abstract excerpt
Notch signaling induces gene expression of the T cell lineage and discourages alternative fate outcomes. Hematopoietic deficiency in the Notch target Hes1 results in severe T cell lineage defects; however, the underlying mechanism is unknown. We found here that Hes1 constrained myeloid gene-expression programs in T cell progenitor cells, as deletion of the myeloid regulator C/EBP-α restored the development of T...
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