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Article

GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate

6 Apr 2016

Abstract excerpt

The gradual reprogramming of haematopoietic precursors into the T-cell fate is characterized by at least two sequential developmental stages. Following Notch1-dependent T-cell lineage specification during which the first T-cell lineage genes are expressed and myeloid and dendritic cell potential is lost, T-cell specific transcription factors subsequently induce T-cell commitment by repressing residual natural...

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PMID: 27048872
DOI: 10.1038/ncomms11171

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