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Article

Enforced Expression of Spi-B Reverses T Lineage Commitment and Blocks β-Selection

1 May 2005

Abstract excerpt

The molecular changes that restrict multipotent murine thymocytes to the T cell lineage and render them responsive to Ag receptor signals remain poorly understood. In this study, we report our analysis of the role of the Ets transcription factor, Spi-B, in this process. Spi-B expression is acutely induced coincident with T cell lineage commitment at the CD4(-)CD8(-)CD44(-)CD25(+) (DN3) stage of thymocyte...

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PMID: 15879115
DOI: 10.4049/jimmunol.174.10.6184

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Enforced Expression of Spi-B Reverses T Lineage Commitment and Blocks β-SelectionPMID 15879115Read ↗

Spi-B is critical for plasmacytoid dendritic cell function and development.Semantic proximity Read ↗

Spi-1 and Spi-B control the expression of the Grap2 gene in B cells.Semantic proximity Read ↗

T cell development requires constraint of the myeloid regulator C/EBP-α by the Notch target and transcriptional repressor Hes1.Semantic proximity Read ↗

Phosphorylation of the Spi-B transcription factor reduces its intrinsic stability.Semantic proximity Read ↗

The gene encoding the transcription factor Spi-B maps to mouse chromosome 7.Semantic proximity Read ↗

The Ets factor Spi-B is a direct critical target of the coactivator OBF-1.Semantic proximity Read ↗

The role of erk1 and erk2 in multiple stages of T cell development.Semantic proximity Read ↗

Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB.Semantic proximity Read ↗

SPI-C, a PU-box binding ETS protein expressed temporarily during B-cell development and in macrophages, contains an acidic transactivation domain located to the N-terminus.Semantic proximity Read ↗

The Ets-1 transcription factor is required for complete pre-T cell receptor function and allelic exclusion at the T cell receptor beta locus.Semantic proximity Read ↗

Transcription factor miz-1 is required to regulate interleukin-7 receptor signaling at early commitment stages of B cell differentiation.Semantic proximity Read ↗

The mechanism of action of Spi-B in the transcriptional activation of the interferon-α4 gene.Semantic proximity Read ↗

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