Article
Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1.
Blood - 15 Nov 2007
Wouters Bas J, Jordà Meritxell Alberich, Keeshan Karen, Louwers Irene, Erpelinck-Verschueren Claudia A J, Tielemans Dennis, Langerak Anton W, He Yiping, Yashiro-Ohtani Yumi, Zhang Pu, Hetherington Christopher J, Verhaak Roel G W, Valk Peter J M, Löwenberg Bob, Tenen Daniel G, Pear Warren S, Delwel Ruud
Abstract excerpt
Gene expression profiling of acute myeloid leukemia (AML) allows the discovery of previously unrecognized molecular entities. Here, we identified a specific subgroup of AML, defined by an expression profile resembling that of AMLs with mutations in the myeloid transcription factor CCAAT/enhancer-binding protein alpha (C/EBPalpha), while lacking such mutations. We found that in these leukemias, the CEBPA gene was...
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