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Article

Conserved inhibitory role of teleost SOCS-1s in IFN signaling pathways.

Developmental and comparative immunology - 1 Mar 2014

Nie Li, Xiong Ran, Zhang Ying-Sheng, Zhu Lv-yun, Shao Jian-Zhong, Xiang Li-Xin

Abstract excerpt

The suppressor of cytokine signaling 1 (SOCS-1) protein is a critical regulator in the immune systems of humans and mammals, which functions classically as an inhibitor of the IFN signaling pathways. However, data on functional characterisation of SOCS-1 in ancient vertebrates are limited. In this study, we report the function of teleost SOCS-1s in IFN signaling in fish models (zebrafish and Tetraodon) and human...

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Source

Identifiers

PMID: 24183820
DOI: 10.1016/j.dci.2013.10.007

Genes

ISG15

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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