SOCS, Intrinsic Virulence Factors, and Treatment of COVID-19

Abstract excerpt

The suppressor of cytokine signaling (SOCS) family of intracellular checkpoint inhibitors has received little recognition compared to other checkpoint inhibitors. Two members of this family, SOCS1 and SOCS3, are indispensable, since SOCS1 knockout in mice results in neonatal death due to interferon gamma (IFN) induced inflammatory disease, and SOCS3 knockout leads to embryonic lethality. We have shown that SOCS1...

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