Article
Aging as accelerated accumulation of somatic variants: whole-genome sequencing of centenarian and middle-aged monozygotic twin pairs.
Twin research and human genetics : the official journal of the International Society for Twin Studies - 1 Dec 2013
Ye Kai, Beekman Marian, Lameijer Eric-Wubbo, Zhang Yanju, Moed Matthijs H, van den Akker Erik B, Deelen Joris, Houwing-Duistermaat Jeanine J, Kremer Dennis, Anvar Seyed Yahya, Laros Jeroen F J, Jones David, Raine Keiran, Blackburne Ben, Potluri Shobha, Long Quan, Guryev Victor, van der Breggen Ruud, Westendorp Rudi G J, 't Hoen Peter A C, den Dunnen Johan, van Ommen Gert Jan B, Willemsen Gonneke, Pitts Steven J, Cox David R, Ning Zemin, Boomsma Dorret I, Slagboom P Eline
Abstract excerpt
It has been postulated that aging is the consequence of an accelerated accumulation of somatic DNA mutations and that subsequent errors in the primary structure of proteins ultimately reach levels sufficient to affect organismal functions. The technical limitations of detecting somatic changes and the lack of insight about the minimum level of erroneous proteins to cause an error catastrophe hampered any firm...
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