Article
A characterization of postzygotic mutations identified in monozygotic twins.
Human mutation - 1 Oct 2018
Ouwens Klaasjan G, Jansen Rick, Tolhuis Bas, Slagboom P Eline, Penninx Brenda W J H, Boomsma Dorret I
Abstract excerpt
Postzygotic mutations are DNA changes acquired from the zygote stage onwards throughout the lifespan. These changes lead to differences in DNA sequence among cells of an individual, potentially contributing to the etiology of complex disorders. Here we compared whole genome DNA sequence data of two monozygotic twin pairs, 40 and 100 years old, to detect somatic mosaicism. DNA samples were sequenced twice on two...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.