Article
Imprinting status of DLK1 gene in brain tumors and lymphomas.
International journal of oncology - 1 Apr 2004
Yin Dong, Xie Dong, De Vos Sven, Liu Gentao, Miller Carl W, Black Keith L, Koeffler H Phillip
Abstract excerpt
DLK1 and GTL2 are reciprocally imprinted genes on human chromosome 14q32. DLK1 encodes a transmembrane protein that is a paternally expressed gene. The maternally expressed GTL2 allele encodes a non-translated RNA. Many of features of DLK1/GTL2 are remarkably similar to those of the prototypical IGF2/H19 reciprocally imprinted gene pair. Imprinting status of IGF2 has been studied in many types of tumors, and loss...
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