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Article

IL-1α released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts.

Mucosal immunology - 1 May 2014

Suwara M I, Green N J, Borthwick L A, Mann J, Mayer-Barber K D, Barron L, Corris P A, Farrow S N, Wynn T A, Fisher A J, Mann D A

Abstract excerpt

Activation of the innate immune system plays a key role in exacerbations of chronic lung disease, yet the potential role of lung fibroblasts in innate immunity and the identity of epithelial danger signals (alarmins) that may contribute to this process are unclear. The objective of the study was to identify lung epithelial-derived alarmins released during endoplasmic reticulum stress (ER stress) and oxidative...

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Identifiers

PMID: 24172847
DOI: 10.1038/mi.2013.87
PMCID: PMC3931585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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