Article
The danger signal plus DNA damage two-hit hypothesis for chronic inflammation in COPD.
The European respiratory journal - 1 Dec 2013
Aoshiba Kazutetsu, Tsuji Takao, Yamaguchi Kazuhiro, Itoh Masayuki, Nakamura Hiroyuki
Abstract excerpt
Inflammation in chronic obstructive pulmonary disease (COPD) is thought to originate from the activation of innate immunity by a danger signal (first hit), although this mechanism does not readily explain why the inflammation becomes chronic. Here, we propose a two-hit hypothesis explaining why inflammation becomes chronic in patients with COPD. A more severe degree of inflammation exists in the lungs of patients...
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