Article
Plastin polymorphisms predict gender- and stage-specific colon cancer recurrence after adjuvant chemotherapy.
Molecular cancer therapeutics - 1 Feb 2014
Ning Yan, Gerger Armin, Zhang Wu, Hanna Diana L, Yang Dongyun, Winder Thomas, Wakatsuki Takeru, Labonte Melissa J, Stintzing Sebastian, Volz Nico, Sunakawa Yu, Stremitzer Stefan, El-Khoueiry Rita, Lenz Heinz-Josef
Abstract excerpt
Tumor recurrence after curative resection remains a major problem in patients with locally advanced colorectal cancer treated with adjuvant chemotherapy. Genetic single-nucleotide polymorphisms (SNP) may serve as useful molecular markers to predict clinical outcomes in these patients and identify targets for future drug development. Recent in vitro and in vivo studies have demonstrated that the plastin genes PLS3...
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