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Article

Common cancer stem cell gene variants predict colon cancer recurrence.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2011

Gerger Armin, Zhang Wu, Yang Dongyun, Bohanes Pierre, Ning Yan, Winder Thomas, LaBonte Melissa J, Wilson Peter M, Benhaim Leonor, Paez David, El-Khoueiry Rita, El-Khoueiry Anthony, Kahn Michael, Lenz Heinz-Josef

Abstract excerpt

PURPOSE: Recent evidence suggests that cancer stem cells (CSC) are responsible for key elements of colon cancer progression and recurrence. Germline variants in CSC genes may result in altered gene function and/or activity, thereby causing interindividual differences in a patient's tumor recurrence capacity and chemoresistance. We investigated germline polymorphisms in a comprehensive panel of CSC genes to...

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Source

Identifiers

PMID: 21918173
DOI: 10.1158/1078-0432.CCR-11-1180

Genes

TTR
ALCAM
DPP4
ITGB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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