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Article

Integrin genetic variants and stage-specific tumor recurrence in patients with stage II and III colon cancer.

The pharmacogenomics journal - 1 Jun 2015

Bohanes P, Yang D, Loupakis F, LaBonte M J, Gerger A, Ning Y, Lenz C, Lenz F, Wakatsuki T, Zhang W, Benhaim L, El-Khoueiry A, El-Khoueiry R, Lenz H-J

Abstract excerpt

Integrins (ITGs) are key elements in cancer biology, regulating tumor growth, angiogenesis and lymphangiogenesis through interactions of the tumor cells with the microenvironment. Moving from the hypothesis that ITGs could have different effects in stage II and III colon cancer, we tested whether a comprehensive panel of germline single-nucleotide polymorphisms (SNPs) in ITG genes could predict stage-specific...

Read the complete abstract on PubMed

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Share to Antimetabolites, Antineoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasm Recurrence, Local

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Source

Identifiers

PMID: 25487679
DOI: 10.1038/tpj.2014.66

Genes

ITGB3
ITGA4
ITGB1
TTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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