Article
Genetic Variants of Matrix Metalloproteinase and Sepsis: The Need Speed Study.
Biomolecules - 9 Feb 2022
Fiotti Nicola, Mearelli Filippo, Di Girolamo Filippo Giorgio, Castello Luigi Mario, Nunnari Alessio, Di Somma Salvatore, Lupia Enrico, Colonetti Efrem, Muiesan Maria Lorenza, Montrucchio Giuseppe, Giansante Carlo, Avanzi Gian Carlo, Biolo Gianni
Abstract excerpt
Many causal mechanisms in sepsis susceptibility are largely unknown and the functional genetic polymorphisms (GP) of matrix metalloproteinases (MMPs) and their natural tissue inhibitor of MMPs (TIMP1) could play a role in its development. GPs of MMPs and TIMP (namely MMP-1 rs1799750, MMP-3 rs3025058, MMP-8 rs11225395, MMP-9 rs2234681, and TIMP-1 rs4898) have been compared in 1058 patients with suspected sepsis to...