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Functional Toll-like receptor 4 mutations modulate the response to fibrinogen

1 Jan 2008

Abstract excerpt

Fibrinogen has been implicated in atherosclerosis; in part by activating the lipopolysaccharide (LPS) receptor Toll-like receptor 4 (TLR4). The fibrinogen-TLR4 signalling pathway remains uncharacterised. In human macrophages fibrinogen stimulated interleukin (IL)6 expression and ERK (extracellular signal-related kinase) phosphorylation. In HEK293-CD14-MD2 cells expressing TLR4, fibrinogen induced robust...

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Identifiers

PMID: 18690351
DOI: 10.1160/th08-03-0179

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