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Article

Association of IL-1RAcP rs16865597 gene polymorphism with susceptibility to essential hypertension: a case-control study in the Chinese Han population.

BMC cardiovascular disorders - 12 Mar 2025

Wu Fangqin, Liu Dongchen, Xia Xin, Yang Xinlei, Huang Suli, Jiang Xinghua, LuLi

Abstract excerpt

BACKGROUND: The IL-33/ST2 pathway plays a crucial role in the development of essential hypertension (EH). This study aimed to investigate the relationship between EH and genetic variations in this pathway in the Chinese Han population. METHODS: A total of 1,151 EH patients and 1,135 healthy controls were included in the study. Sixteen single nucleotide polymorphisms (SNPs) in the interleukin-33 (IL-33) and...

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Blood Pressure
Case-Control Studies
China
East Asian People
Essential Hypertension

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Genetic Association Studies

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PMID: 40075282
DOI: 10.1186/s12872-025-04629-4
PMCID: PMC11900220

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