Article
The -308 polymorphism in the promoter region of the tumor necrosis factor-alpha (TNF-alpha) gene and ex vivo lipopolysaccharide-induced TNF-alpha expression in patients with aggressive periodontitis and/or type 1 diabetes mellitus.
European cytokine network - 1 Jan 2000
Pérez Claudio, González Fermín E, Pavez Violeta, Araya Aida V, Aguirre Adam, Cruzat Andrea, Contreras-Levicoy Juan, Dotte Andrés, Aravena Octavio, Salazar Lorena, Catalán Diego, Cuenca Jimena, Ferreira Arturo, Schiattino Irene, Aguillón Juan C
Abstract excerpt
Several single-nucleotide polymorphisms (SNPs) have been identified in the TNF-alpha gene promoter. The transition G-->A at position -308 generates the TNF-alpha1 (G/G) and TNF-alpha2 (G/A or A/A) alleles, where the polymorphic TNF-alpha2 allele is associated with a high, in vitro TNF-alpha expression and an increased susceptibility to diverse illnesses. Here we study the association of the -308 TNF-alpha SNP...
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