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Article

The -251 A/T Polymorphism in the IL8 Promoter is a Risk Factor for Acute Pancreatitis.

Pancreas - 1 Jan 2018

Bishu Shrinivas, Koutroumpakis Efstratios, Mounzer Rawad, Stello Kimberly, Pollock Nijole, Evans Anna, Whitcomb David C, Papachristou Georgios I

Abstract excerpt

OBJECTIVES: Inflammation in the setting of acute pancreatitis (AP) is partially driven by pathogen recognition receptors that recognize damage-associated molecular patterns. Interleukin (IL)-8 is a chemotactic factor produced by pathogen recognition receptor-expressing cells. A single-nucleotide polymorphism in IL8 promoter region (-251 A/T) has been implicated in inflammatory diseases. We examined whether this...

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Identifiers

PMID: 29215544
DOI: 10.1097/MPA.0000000000000967
PMCID: PMC5728433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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