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Article

PAI-1 genetic polymorphisms influence septic patients' outcomes by regulating neutrophil activity.

Chinese medical journal - 20 Aug 2023

Jiang Shaowei, Wang Yang, Chen Liang, Mu Honghua, Meaney Connor, Fan Yiwen, Pillay Janesh, Wang Hairong, Zhang Jincheng, Pan Shuming, Gao Chengjin

Abstract excerpt

BACKGROUND: Plasminogen activator inhibitor-1 (PAI-1) plays an important role in the pathophysiology of sepsis, but the exact mechanism remains debatable. In this study, we investigated the associations among the serum levels of PAI-1, the incidence of 4G/5G promoter PAI-1 gene polymorphisms, immunological indicators, and clinical outcomes in septic patients. METHODS: A total of 181 patients aged 18-80 years with...

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Identifiers

PMID: 37439338
DOI: 10.1097/CM9.0000000000002316
PMCID: PMC10431590

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