Article
The C-reactive protein (+)1444C/T alteration modulates the inflammation and coagulation response in human endotoxemia.
Clinical chemistry - 1 Oct 2006
Marsik Claudia, Sunder-Plassmann Raute, Jilma Bernd, Kovar Florian M, Mannhalter Christine, Wagner Oswald, Rumpold Helmut, Endler Georg
Abstract excerpt
BACKGROUND: C-reactive protein (CRP) plays a major role in the immune system and is an independent risk marker of cardiovascular disease. However, CRP's role in atherogenesis as innocent bystander, causative, or even protective agent, remains unresolved. The (+)1444C/T alteration in the CRP gene has been reported to determine basal CRP concentrations. We hypothesized that this alteration may also be associated...
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