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Article

Unexpected interaction between CYP3A4 and BI 11634: is BI 11634 interacting with CYP3A4 similar to nifedipine?

Drug metabolism and drug interactions - 1 Jan 2013

Mathur Arti, Tweedie Donald J, Maw Holly Hlaing-Hlaing, Li Yongmei

Abstract excerpt

BACKGROUND: Interactions between cytochrome P450 3A4 (CYP3A4) and its substrates are complex with multiple binding sites within the active site. BI 11634 is a factor Xa inhibitor in drug development and its interaction with CYP3A4 was evaluated. METHODS: Reaction phenotyping studies were conducted to determine human isoform(s) of cytochrome P450 responsible for BI 11634 metabolism using recombinant CYPs and...

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Identifiers

PMID: 24166670
DOI: 10.1515/dmdi-2013-0044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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