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Article

T-cell immunoglobulin and mucin domain 2 (TIM-2) is a target of ADAM10-mediated ectodomain shedding.

The FEBS journal - 1 Jan 2014

Dewitz Christin, Möller-Hackbarth Katja, Schweigert Olga, Reiss Karina, Chalaris Athena, Scheller Jürgen, Rose-John Stefan

Abstract excerpt

T-cell immunoglobulin and mucin domain (TIM)-2 is expressed on activated B cells. Here, we provide evidence that murine TIM-2 is a target of ADAM10-mediated ectodomain shedding, resulting in the generation of a soluble form of TIM-2. We identified ADAM10 but not ADAM17 as the major sheddase of TIM-2, as shown by pharmacological ADAM10 inhibition and with ADAM10-deficient and ADAM17-deficient murine embryonic...

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Source

Identifiers

PMID: 24164679
DOI: 10.1111/febs.12583

Genes

ADAM10
ADAM17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Research trail→

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T-cell immunoglobulin and mucin domain 2 (TIM-2) is a target of ADAM10-mediated ectodomain shedding.PMID 24164679Read ↗

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