Article
Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis.
Haematologica - 1 Jun 2009
Ramsay Andrew J, Hooper John D, Folgueras Alicia R, Velasco Gloria, López-Otín Carlos
Abstract excerpt
Maintaining the body's levels of iron within precise boundaries is essential for normal physiological function. Alterations of these levels below or above the healthy limit lead to a systemic deficiency or overload in iron. The type-two transmembrane serine protease (TTSP), matriptase-2 (also known as TMPRSS6), is attracting significant amounts of interest due to its recently described role in iron homeostasis....
Topics
- Anemia, Iron-Deficiency
- Animals
- Homeostasis
- Humans
- Iron
- Membrane Proteins
- Models, Biological
- Mutation
- Serine Endopeptidases