Article
Genetic variants in selenoprotein P plasma 1 gene (SEPP1) are associated with fasting insulin and first phase insulin response in Hispanics.
Gene - 15 Jan 2014
Hellwege Jacklyn N, Palmer Nicholette D, Ziegler Julie T, Langefeld Carl D, Lorenzo Carlos, Norris Jill M, Takamura Toshinari, Bowden Donald W
Abstract excerpt
CONTEXT: Insulin resistance is not fully explained on a molecular level, though several genes and proteins have been tied to this defect. Knockdowns of the SEPP1 gene, which encodes the selenoprotein P (SeP) protein, have been shown to increase insulin sensitivity in mice. SeP is a liver-derived plasma protein and a major supplier of selenium, which is a proposed insulin mimetic and antidiabetic agent. OBJECTIVE:...
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