Article
Candidate loci for insulin sensitivity and disposition index from a genome-wide association analysis of Hispanic participants in the Insulin Resistance Atherosclerosis (IRAS) Family Study.
Diabetologia - 1 Feb 2010
Palmer N D, Langefeld C D, Ziegler J T, Hsu F, Haffner S M, Fingerlin T, Norris J M, Chen Y I, Rich S S, Haritunians T, Taylor K D, Bergman R N, Rotter J I, Bowden D W
Abstract excerpt
AIMS/HYPOTHESIS: The majority of type 2 diabetes genome-wide association studies (GWAS) to date have been performed in European-derived populations and have identified few variants that mediate their effect through insulin resistance. The aim of this study was to evaluate two quantitative, directly assessed measures of insulin resistance, namely insulin sensitivity index (S(I)) and insulin disposition index (DI),...
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