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Article

ENPP1 gene, insulin resistance and related clinical outcomes.

Current opinion in clinical nutrition and metabolic care - 1 Jul 2007

Bacci Simonetta, De Cosmo Salvatore, Prudente Sabrina, Trischitta Vincenzo

Abstract excerpt

PURPOSE OF REVIEW: Insulin resistance plays a significant role in both morbidity and mortality of the general population. Understanding the molecular mechanisms of insulin resistance would help the identification of at-risk individuals in the presymptomatic stage, and the discovery of novel and more effective treatments. The transmembrane glycoprotein ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1)...

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Share to Diabetes Mellitus, Type 2
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Insulin Resistance

Share to Mutation, Missense

Share to Obesity

Share to Phosphoric Diester Hydrolases

Share to Pyrophosphatases

Share to Signal Transduction

Source

Identifiers

PMID: 17563456
DOI: 10.1097/MCO.0b013e3281e386c9

Genes

ENPP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

ENPP1 gene, insulin resistance and related clinical outcomes.PMID 17563456Read ↗

The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects.Semantic proximity Read ↗

Role of the ENPP1 K121Q polymorphism in glucose homeostasis.Semantic proximity Read ↗

Haplotype structure of the ENPP1 Gene and Nominal Association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study.Semantic proximity Read ↗

Association of the ENPP1 K121Q polymorphism with susceptibility to type 2 diabetes in different populations: evidence based on 40 studies.Semantic proximity Read ↗

ENPP1/PC-1 gene K121Q polymorphism is associated with obesity in European adult populations: evidence from a meta-analysis involving 24,324 subjects.Semantic proximity Read ↗

New polymorphism of ENPP1 (PC-1) is associated with increased risk of type 2 diabetes among obese individuals.Semantic proximity Read ↗

The association of ENPP1 K121Q with diabetes incidence is abolished by lifestyle modification in the diabetes prevention program.Semantic proximity Read ↗

K121Q ENPP1/PC-1 gene polymorphism is associated with insulin resistance in a North Indian population.Semantic proximity Read ↗

ENPP1 K121Q polymorphism and obesity, hyperglycaemia and type 2 diabetes in the prospective DESIR Study.Semantic proximity Read ↗

Association of the Q121 variant of ENPP1 gene with decreased kidney function among patients with type 2 diabetes.Semantic proximity Read ↗

ENPP1 variants and haplotypes predispose to early onset obesity and impaired glucose and insulin metabolism in German obese children.Semantic proximity Read ↗

[The analysis of association between ENPP1 K121Q polymorphism and risk factors of type 2 diabetes mellitus in ukrainian population].Semantic proximity Read ↗

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