Article
Immunohistochemistry as first-line screening for detecting colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome: a 2-antibody panel may be as predictive as a 4-antibody panel.
The American journal of surgical pathology - 1 Nov 2009
Shia Jinru, Tang Laura H, Vakiani Efsevia, Guillem Jose G, Stadler Zsofia K, Soslow Robert A, Katabi Nora, Weiser Martin R, Paty Philip B, Temple Larissa K, Nash Garrett M, Wong W Douglas, Offit Kenneth, Klimstra David S
Abstract excerpt
The utility of immunohistochemical detection of DNA mismatch repair proteins in screening colorectal cancer for hereditary nonpolyposis colorectal cancer (HNPCC) is being widely investigated. Currently, in both research and clinical settings, a 4-antibody panel that includes the 4 most commonly affected proteins (MLH1, MSH2, MSH6, and PMS2) is being used generally. On the basis of the biochemical properties of...
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