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Article

Adaptive mutations in the nuclear export protein of human-derived H5N1 strains facilitate a polymerase activity-enhancing conformation.

Journal of virology - 1 Jan 2014

Reuther Peter, Giese Sebastian, Götz Veronika, Kilb Normann, Mänz Benjamin, Brunotte Linda, Schwemmle Martin

Abstract excerpt

The nuclear export protein (NEP) (NS2) of the highly pathogenic human-derived H5N1 strain A/Thailand/1(KAN-1)/2004 with the adaptive mutation M16I greatly enhances the polymerase activity in human cells in a concentration-dependent manner. While low NEP levels enhance the polymerase activity, high levels are inhibitory. To gain insights into the underlying mechanism, we analyzed the effect of NEP deletion mutants...

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Source

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Identifiers

PMID: 24155389
DOI: 10.1128/JVI.01495-13
PMCID: PMC3911765

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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