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Article

The role of the N-terminal caspase cleavage site in the nucleoprotein of influenza A virus in vitro and in vivo.

Archives of virology - 1 Jan 2008

Lipatov A S, Yen H-L, Salomon R, Ozaki H, Hoffmann E, Webster R G

Abstract excerpt

The N-terminal caspase cleavage in the nucleoprotein (NP) of influenza A virus is correlated with the host origin of the virus, thus could be a molecular determinant for host range. We studied how mutations targeting the NP cleavage motif of human and avian influenza viruses affect virus replication in vitro and in vivo. The "avian-like" D16-->G substitution in the NP, which makes this protein resistant to...

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Identifiers

PMID: 18058063
DOI: 10.1007/s00705-007-0003-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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