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Article

Generation of influenza A virus NS2 (NEP) mutants with an altered nuclear export signal sequence.

Journal of virology - 1 Sept 2004

Iwatsuki-Horimoto Kiyoko, Horimoto Taisuke, Fujii Yutaka, Kawaoka Yoshihiro

Abstract excerpt

The NS2 (NEP) protein of influenza A virus contains a highly conserved nuclear export signal (NES) motif in its amino-terminal region (12ILMRMSKMQL21, A/WSN/33), which is thought to be required for nuclear export of viral ribonucleoprotein complexes (vRNPs) mediated by a cellular export factor, CRM1. However, simultaneous replacement of three hydrophobic residues in the NES with alanine does not affect NS2 (NEP)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15331747
DOI: 10.1128/JVI.78.18.10149-10155.2004
PMCID: PMC514982

Genes

NES

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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