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Article

The intrinsically unstructured domain of PC4 modulates the activity of the structured core through inter- and intramolecular interactions.

Biochemistry - 18 Apr 2006

Jonker Hendrik R A, Wechselberger Rainer W, Boelens Rolf, Kaptein Rob, Folkers Gert E

Abstract excerpt

Proteins frequently contain unstructured regions apart from a functionally important and well-conserved structured domain. Functional and structural aspects for these regions are frequently less clear. The general human positive cofactor 4 (PC4), has such a domain organization and can interact with various DNA substrates, transcriptional activators, and basal transcription factors. While essential for the...

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PMID: 16605275
DOI: 10.1021/bi052531b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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