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Article

Glioblastomas are composed of genetically divergent clones with distinct tumourigenic potential and variable stem cell-associated phenotypes.

Acta neuropathologica - 1 Feb 2014

Stieber Daniel, Golebiewska Anna, Evers Lisa, Lenkiewicz Elizabeth, Brons Nicolaas H C, Nicot Nathalie, Oudin Anaïs, Bougnaud Sébastien, Hertel Frank, Bjerkvig Rolf, Vallar Laurent, Barrett Michael T, Niclou Simone P

Abstract excerpt

Glioblastoma (GBM) is known to be a heterogeneous disease; however, the genetic composition of the cells within a given tumour is only poorly explored. In the advent of personalised medicine the understanding of intra-tumoural heterogeneity at the cellular and the genetic level is mandatory to improve treatment and clinical outcome. By combining ploidy-based flow sorting with array-comparative genomic...

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Identifiers

PMID: 24154962
DOI: 10.1007/s00401-013-1196-4
PMCID: PMC3895194

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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