Article
Contact transmission of influenza virus between ferrets imposes a looser bottleneck than respiratory droplet transmission allowing propagation of antiviral resistance.
Scientific reports - 19 Jul 2016
Frise Rebecca, Bradley Konrad, van Doremalen Neeltje, Galiano Monica, Elderfield Ruth A, Stilwell Peter, Ashcroft Jonathan W, Fernandez-Alonso Mirian, Miah Shahjahan, Lackenby Angie, Roberts Kim L, Donnelly Christl A, Barclay Wendy S
Abstract excerpt
Influenza viruses cause annual seasonal epidemics and occasional pandemics. It is important to elucidate the stringency of bottlenecks during transmission to shed light on mechanisms that underlie the evolution and propagation of antigenic drift, host range switching or drug resistance. The virus spreads between people by different routes, including through the air in droplets and aerosols, and by direct contact....
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