Article
Mutations Driving Airborne Transmission of A/H5N1 Virus in Mammals Cause Substantial Attenuation in Chickens only when combined.
Scientific reports - 3 Aug 2017
Richard Mathilde, Herfst Sander, van den Brand Judith M A, de Meulder Dennis, Lexmond Pascal, Bestebroer Theo M, Fouchier Ron A M
Abstract excerpt
A/H5N1 influenza viruses pose a threat to human and animal health. A fully avian A/H5N1 influenza virus was previously shown to acquire airborne transmissibility between ferrets upon accumulation of five or six substitutions that affected three traits: polymerase activity, hemagglutinin stability and receptor binding. Here, the impact of these traits on A/H5N1 virus replication, tissue tropism, pathogenesis and...
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