Underestimation of heritability using a mixed model with a polygenic covariance structure in a genome-wide association study for complex traits.

Abstract excerpt

Recently, the use of a mixed model methodology in genome-wide association studies (GWAS) has been considered effective for controlling population stratification and explaining the polygenic effects of complex traits. However, estimating polygenic variance components and heritability was biased when the mixed model was used. This bias results from a diluted genetic relationship covariance structure, particularly...

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