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Article

Using the realized relationship matrix to disentangle confounding factors for the estimation of genetic variance components of complex traits.

Genetics, selection, evolution : GSE - 15 Jun 2010

Lee Sang Hong, Goddard Michael E, Visscher Peter M, van der Werf Julius Hj

Abstract excerpt

BACKGROUND: In the analysis of complex traits, genetic effects can be confounded with non-genetic effects, especially when using full-sib families. Dominance and epistatic effects are typically confounded with additive genetic and non-genetic effects. This confounding may cause the estimated genetic variance components to be inaccurate and biased. METHODS: In this study, we constructed genetic covariance...

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Identifiers

PMID: 20546624
DOI: 10.1186/1297-9686-42-22
PMCID: PMC2903499

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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