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Article

SIRPα polymorphisms, but not the prion protein, control phagocytosis of apoptotic cells.

The Journal of experimental medicine - 18 Nov 2013

Nuvolone Mario, Kana Veronika, Hutter Gregor, Sakata Daiji, Mortin-Toth Steven M, Russo Giancarlo, Danska Jayne S, Aguzzi Adriano

Abstract excerpt

Prnp(-/-) mice lack the prion protein PrP(C) and are resistant to prion infections, but variable phenotypes have been reported in Prnp(-/-) mice and the physiological function of PrP(C) remains poorly understood. Here we examined a cell-autonomous phenotype, inhibition of macrophage phagocytosis of apoptotic cells, previously reported in Prnp(-/-) mice. Using formal genetic, genomic, and immunological analyses,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24145514
DOI: 10.1084/jem.20131274
PMCID: PMC3832919

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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