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Article

Prion protein protects human neurons against Bax-mediated apoptosis.

The Journal of biological chemistry - 19 Oct 2001

Bounhar Y, Zhang Y, Goodyer C G, LeBlanc A

Abstract excerpt

The function of the cellular prion protein (PrP) is still poorly understood. We present here an unprecedented role for PrP against Bax-mediated neuronal apoptosis and show that PrP potently inhibits Bax-induced cell death in human primary neurons. Deletion of four octapeptide repeats of PrP (PrPDeltaOR) and familial D178N and T183A PrP mutations completely or partially eliminate the neuroprotective effect of PrP....

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PMID: 11522774
DOI: 10.1074/jbc.C100443200

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Prion protein protects human neurons against Bax-mediated apoptosis.PMID 11522774Read ↗

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