Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein.

Proceedings of the National Academy of Sciences of the United States of America - 26 Jun 2007

Parkin Edward T, Watt Nicole T, Hussain Ishrut, Eckman Elizabeth A, Eckman Christopher B, Manson Jean C, Baybutt Herbert N, Turner Anthony J, Hooper Nigel M

Abstract excerpt

Proteolytic processing of the amyloid precursor protein (APP) by beta-secretase, beta-site APP cleaving enzyme (BACE1), is the initial step in the production of the amyloid beta (Abeta) peptide, which is involved in the pathogenesis of Alzheimer's disease. The normal cellular function of the prion protein (PrP(C)), the causative agent of the transmissible spongiform encephalopathies such as Creutzfeldt-Jakob...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amyloid beta-Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloid beta-Protein Precursor

Share to Amyloid Precursor Protein Secretases

Share to Binding Sites

Share to Membrane Microdomains

Share to Prion Diseases

Share to Prions

Source

Open in PubMed Open full text

Identifiers

PMID: 17573534
DOI: 10.1073/pnas.0609621104
PMCID: PMC1904148

Genes

APP
BACE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein.PMID 17573534Read ↗

Impact of the cellular prion protein on amyloid-β and 3PO-tau processing.Semantic proximity Read ↗

Prion neurotoxicity: insights from prion protein mutants.Semantic proximity Read ↗

Prion protein and agingSemantic proximity Read ↗

Insights into the physiological function of cellular prion protein.Semantic proximity Read ↗

N-Terminal Regions of Prion Protein: Functions and Roles in Prion Diseases.Semantic proximity Read ↗

Cellular mechanisms of beta-amyloid production and secretion.Semantic proximity Read ↗

Conditional Deletion of <i>Prnp</i> Rescues Behavioral and Synaptic Deficits after Disease Onset in Transgenic Alzheimer's DiseaseSemantic proximity Read ↗

Stress-protective signalling of prion protein is corrupted by scrapie prions.Semantic proximity Read ↗

The N-terminal, polybasic region is critical for prion protein neuroprotective activity.Semantic proximity Read ↗

The multiple functions of PrPC in physiological, cancer, and neurodegenerative contextsSemantic proximity Read ↗

Cellular prion protein acts as mediator of amyloid beta uptake by caveolin‐1 causing cellular dysfunctions in vitro and in vivoSemantic proximity Read ↗

Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.