Article
Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrPSc, even upon LPS stimulation.
Glia - 1 Dec 2010
Hughes Martina M, Field Robert H, Perry V Hugh, Murray Carol L, Cunningham Colm
Abstract excerpt
Despite the phagocytic machinery available to microglia the aberrant amyloid proteins produced during Alzheimer's and prion disease, amyloid-β and PrP(Sc), are inefficiently cleared. We have shown that microglia in the ME7 model of prion disease show morphological evidence of activation, synthesize low levels of pro-inflammatory cytokines and are primed to produce exaggerated responses to subsequent inflammatory...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.