Article
129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal.
Molecular neurobiology - 1 Jan 1994
Manson J C, Clarke A R, Hooper M L, Aitchison L, McConnell I, Hope J
Abstract excerpt
The neural membrane glycoprotein PrP is implicated in the pathogenesis of the transmissible spongiform encephalopathies; however, the normal function of PrP and its precise role in disease are not understood. Recently, gene targeting has been used to produce mice with neo/PrP fusion transcripts, but no detectable PrP protein in the brain (1). Here we report the use of a different targeting strategy, to produce...
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