Article
129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal.
Molecular neurobiology - 1 Jan 2000
Manson J C, Clarke A R, Hooper M L, Aitchison L, McConnell I, Hope J
Abstract excerpt
The neural membrane glycoprotein PrP is implicated in the pathogenesis of the transmissible spongiform encephalopathies; however, the normal function of PrP and its precise role in disease are not understood. Recently, gene targeting has been used to produce mice with neo/PrP fusion transcripts,...
Topics
- Aging
- Animals
- Blotting, Northern
- Brain
- Chimera
- Embryo, Mammalian
- Gene Expression
- Genetic Vectors
- Heterozygote
- Homozygote
- Mice
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Mice, Mutant Strains
- Mutation
- Prions
- RNA, Messenger
- Reference Values