Article
Genetic polymorphisms potentially associated with response to metformin in postmenopausal diabetics suffering and not suffering with cancer.
Cell cycle (Georgetown, Tex.) - 1 Dec 2013
Berstein Lev M, Iyevleva Aglaya G, Vasilyev Dmitry, Poroshina Tatyana E, Imyanitov Evgeny N
Abstract excerpt
Metformin is a well-known antidiabetic medication, which, besides diabetes, may be involved into modulation of other age-related pathologies, including cancer. The study concerns 12 gene polymorphisms divided into 2 groups consisting of 6 genes each. The first group was composed from so-called "standard" (S) polymorphisms, for which the connection with metabolic response to metformin is already established. The...
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