Article
Context-dependent adaption of EpCAM expression in early systemic esophageal cancer.
Oncogene - 9 Oct 2014
Driemel C, Kremling H, Schumacher S, Will D, Wolters J, Lindenlauf N, Mack B, Baldus S A, Hoya V, Pietsch J M, Panagiotidou P, Raba K, Vay C, Vallböhmer D, Harréus U, Knoefel W T, Stoecklein N H, Gires O
Abstract excerpt
The role of the epithelial cell adhesion molecule EpCAM in cancer progression remains largely unclear. High expression of EpCAM in primary tumors is often associated with more aggressive phenotypes and EpCAM is the prime epithelial antigen in use to isolate circulating tumor cells (CTCs) and characterize disseminated tumor cells (DTCs). However, reduced expression of EpCAM was associated with...
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