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Article

Phenotype-dependent effects of EpCAM expression on growth and invasion of human breast cancer cell lines.

BMC cancer - 30 Oct 2012

Martowicz Agnieszka, Spizzo Gilbert, Gastl Guenther, Untergasser Gerold

Abstract excerpt

BACKGROUND: The epithelial cell adhesion molecule (EpCAM) has been shown to be overexpressed in breast cancer and stem cells and has emerged as an attractive target for immunotherapy of breast cancer patients. This study analyzes the effects of EpCAM on breast cancer cell lines with epithelial or mesenchymal phenotype. METHODS: For this purpose, shRNA-mediated knockdown of EpCAM gene expression was performed in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23110550
DOI: 10.1186/1471-2407-12-501
PMCID: PMC3519683

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