Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mammalian Prion protein expression in yeast; a model for transmembrane insertion.

Prion - 1 Jan 2000

Tipper Donald, Martinez-Vilchez Immaculada, Markgren Lucas, Kagalwala Din Z

Abstract excerpt

The prion protein (PrP), a GPI-anchored glycoprotein, is inefficiently secreted by mammalian microsomes, 50% being found as transmembrane (TM) proteins with the central TM1 segment spanning the membrane. TM1 hydrophobicity is marginal for lateral membrane insertion, which is primarily driven by hydrophobic interaction between the ER translocon and substrates in transit. Most inserted TM1 has its N-terminus in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Gene Expression
Share to Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Prions

Share to Protein Transport

Share to Recombinant Fusion Proteins

Share to Saccharomyces cerevisiae

Share to Transformation, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 24141197
DOI: 10.4161/pri.26850
PMCID: PMC4201616

Genes

GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mammalian Prion protein expression in yeast; a model for transmembrane insertion.PMID 24141197Read ↗

Cell surface expression of the prion protein in yeast does not alter copper utilization phenotypes.Semantic proximity Read ↗

Combinatorial control of prion protein biogenesis by the signal sequence and transmembrane domain.Semantic proximity Read ↗

A transmembrane form of the prion protein in neurodegenerative disease.Semantic proximity Read ↗

Signal sequence insufficiency contributes to neurodegeneration caused by transmembrane prion protein.Semantic proximity Read ↗

Polar substitutions in helix 3 of the prion protein produce transmembrane isoforms that disturb vesicle trafficking.Semantic proximity Read ↗

Increasing prion propensity by hydrophobic insertion.Semantic proximity Read ↗

Cotranslational partitioning of nascent prion protein into multiple populations at the translocation channel.Semantic proximity Read ↗

Mutant prion protein-mediated aggregation of normal prion protein in the endoplasmic reticulum: implications for prion propagation and neurotoxicity.Semantic proximity Read ↗

Topics in prion cell biology.Semantic proximity Read ↗

The C-terminal globular domain of the prion protein is necessary and sufficient for import into the endoplasmic reticulum.Semantic proximity Read ↗

Familial CJD Associated PrP Mutants within Transmembrane Region Induced Ctm-PrP Retention in ER and Triggered Apoptosis by ER Stress in SH-SY5Y CellsSemantic proximity Read ↗

(Ctm)PrP and ER stress: a neurotoxic mechanism of some special PrP mutants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.