Article
A transmembrane form of the prion protein in neurodegenerative disease.
Science (New York, N.Y.) - 6 Feb 1998
Hegde R S, Mastrianni J A, Scott M R, DeFea K A, Tremblay P, Torchia M, DeArmond S J, Prusiner S B, Lingappa V R
Abstract excerpt
At the endoplasmic reticulum membrane, the prion protein (PrP) can be synthesized in several topological forms. The role of these different forms was explored with transgenic mice expressing PrP mutations that alter the relative ratios of the topological forms. Expression of a particular transmembrane form (termed CtmPrP) produced neurodegenerative changes in mice similar to those of some genetic prion diseases....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.