Article
A transmembrane form of the prion protein in neurodegenerative disease.
Science (New York, N.Y.) - 6 Feb 1998
Hegde R S, Mastrianni J A, Scott M R, DeFea K A, Tremblay P, Torchia M, DeArmond S J, Prusiner S B, Lingappa V R
Abstract excerpt
At the endoplasmic reticulum membrane, the prion protein (PrP) can be synthesized in several topological forms. The role of these different forms was explored with transgenic mice expressing PrP mutations that alter the relative ratios of the topological forms. Expression of a particular transmem...
Topics
- Amino Acid Sequence
- Animals
- Brain
- Cricetinae
- Endopeptidases
- Endoplasmic Reticulum
- Gerstmann-Straussler-Scheinker Disease
- Humans
- Intracellular Membranes
- Mesocricetus
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- Neurodegenerative Diseases
- PrPC Proteins
- PrPSc Proteins
- Prion Diseases