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Article

Signal sequence insufficiency contributes to neurodegeneration caused by transmembrane prion protein.

The Journal of cell biology - 22 Feb 2010

Rane Neena S, Chakrabarti Oishee, Feigenbaum Lionel, Hegde Ramanujan S

Abstract excerpt

Protein translocation into the endoplasmic reticulum is mediated by signal sequences that vary widely in primary structure. In vitro studies suggest that such signal sequence variations may correspond to subtly different functional properties. Whether comparable functional differences exist in vivo and are of sufficient magnitude to impact organism physiology is unknown. Here, we investigate this issue by...

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Identifiers

PMID: 20156965
DOI: 10.1083/jcb.200911115
PMCID: PMC2828915

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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