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Article

(Ctm)PrP and ER stress: a neurotoxic mechanism of some special PrP mutants.

Prion - 1 Jan 2000

Shi Qi, Dong Xiao-Ping

Abstract excerpt

The pathogenic agent is hypothesized to be PrP(Sc) in prion diseases. However, little accumulation of PrPSc is repeatedly observed in some kinds of natural and experimental prion diseases, including some special genetic human prion diseases. One of the specific topology forms of PrP, (Ctm)PrP, representing a key neurotoxic intermediate in prion disorders, has been testified in cell-free translation systems and...

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Identifiers

PMID: 21795854
DOI: 10.4161/pri.5.3.16327
PMCID: PMC3226035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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